January 1, 2004Chronobiology International
Circadian and Short-Term Regulation of Blood Pressure and Heart Rate in Transgenic Mice with Cardiac Overexpression of The β1-Adrenoceptor
Key result
Cardiac overexpression of the β1-adrenoceptor in young, nonfailing mice resulted in largely preserved circadian and short-term regulation of blood pressure and heart rate compared to wildtype mice.
Why the study?
Does elevated cardiac sympathetic activity (via beta1-adrenoceptor overexpression) alter circadian and short-term variability in blood pressure and heart rate in nonfailing mice?
Population
8 to 9-week-old wildtype and transgenic mice with cardiac overexpression of the beta1-adrenoceptor prior to…
Comparison
Propranolol (500mg/L in drinking water) vs Baseline conditions and wildtype controls
Design
Preclinical
Follow-up
24 hours (continuous monitoring)
Authors
Discussion
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Implication
Sympathetic overactivity alone may not explain lost BP/HR variability in human HF; leaves open mechanisms and requires human validation.
Structured PICO
Does elevated cardiac sympathetic activity (via beta1-adrenoceptor overexpression) alter circadian and short-term variability in blood pressure and heart rate in nonfailing mice?
P
Population
8 to 9-week-old wildtype and transgenic mice with cardiac overexpression of the β1-adrenoceptor prior to the development of overt heart failure.
E
Exposure
Propranolol (500mg/L in drinking water)
C
Comparator
Baseline conditions and wildtype controls
O
Outcome
Circadian and short-term regulation of blood pressure and heart ratesurrogate
Circadian and short-term regulation of blood pressure and heart rate are largely preserved in young, nonfailing beta1-transgenic mice, suggesting that the loss of variability in human heart failure is not solely due to sympathetic overactivity.
Cite This Study
Witte et al. (2004) studied Cardiac overexpression of the β1-adrenoceptor. Cardiac overexpression of the β1-adrenoceptor vs. Wildtype mice was evaluated on Circadian and short-term regulation of blood pressure and heart rate. Cardiac overexpression of the β1-adrenoceptor in young, nonfailing mice resulted in largely preserved circadian and short-term regulation of blood pressure and heart rate compared to wildtype mice.