Key result
Failure to routinely conduct cumulative meta-analyses may have resulted in 41,000 deaths annually from non-use of intravenous dilators, 35,000 from aspirin non-use, and 37,000 from ß-blockers non-use.
Why the study?
Living systematic review methodology was recently developed, and investigators sought to estimate the historical mortality likely resulting from the failure to use this approach.
Does the use of routine prospective cumulative systematic reviews reduce estimated historical mortality in patients with acute myocardial infarction?
Population
Patients who had suffered acute myocardial infarctions
Design
Historical modeling study
Authors
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Delays in adopting proven acute MI therapies persist; extends Antman findings by highlighting ongoing translation gaps for clinicians and researchers.
Does the use of routine prospective cumulative systematic reviews reduce estimated historical mortality in patients with acute myocardial infarction?
The failure to conduct routine prospective cumulative systematic reviews historically delayed the adoption of life-saving therapies and the discontinuation of harmful ones in acute myocardial infarction.
Robert A. Hahn (2021) studied Acute myocardial infarction. Failure to conduct routine prospective cumulative systematic reviews vs. Conducting cumulative meta-analyses was evaluated on Estimated annual deaths attributable to non-use of effective interventions. Failure to routinely conduct cumulative meta-analyses may have resulted in 41,000 deaths annually from non-use of intravenous dilators, 35,000 from aspirin non-use, and 37,000 from ß-blockers non-use.
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