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Inflexibility: Elansolid A was isolated from Chitinophaga sancti (Flexibacter sancti ) as the two separable isomers A1 and A2 (1 and 1*, respectively). Molecular modeling revealed that they are stable atropisomers which are “frozen” by 14 inflexible bonds within the 19-membered macrolide ring. The absolute configuration was established by synthesis of the C1–C11 fragment. Elansolid A2 shows activity against Gram-positive bacteria.
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Steinmetz et al. (2010) studied this question.
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