Key result
Six weeks of high-intensity interval training significantly increased PGC-1α (P=0.001) and eNOS (P=0.001) gene expression in the heart tissue of high-fat diet-induced obese male rats.
Why the study?
Obesity affects cardiac function and induces atherosclerosis, hypertension, and arrhythmias, but the impact of high-intensity interval training on cardiac PGC-1α and eNOS gene expression in obesity required investigation.
Does high-intensity interval training improve PGC-1α and eNOS gene expression in the heart tissue of obese male rats?
Does high-intensity interval training improve PGC-1α and eNOS gene expression in the heart tissue of obese male rats?
p-value: p=0.001
Six weeks of high-intensity interval training significantly improves the expression of PGC-1α and eNOS genes in the heart tissue of obese rats, suggesting a molecular mechanism for cardiovascular benefits of exercise in obesity.
HIIT upregulates cardiac PGC-1α and eNOS in obese rats; leaves open translation to human obesity-related cardiac dysfunction.
Background: Nowadays, obesity can affect heart function and induced atherosclerosis, high blood pressure, and heart arrhythmia, which has become a major problem for global health. Objectives: The present study aimed to review the effect of six weeks of high-intensity interval training (HIIT) on gene expression levels of PGC-1α and eNOS in the heart tissue of obese male rats. Methods: In this experimental study, 14 high-fat diet (HFD)-induced obese rats were divided into two groups of control and training. Also, 7 rats were placed in a non-obese control group to investigate the effects of obesity on research variables. During six weeks, rats in the training group performed HIIT three days per week. After six weeks, all rats were sacrificed, and their heart tissue was removed to measure the PGC-1α and eNOS gene expression. We used one-way ANOVA with Tukey’s post hoc tests (P ≤ 0.05) for statistical analysis. Results: HFD significantly decreased PGC-1α (P = 0.04) and eNOS (P = 0.001) gene expression, but HIIT significantly increased PGC-1α (P = 001) and eNOS (P = 0.001) gene expression. Conclusions: HIIT seems to improve cardiac gene expression levels of PGC-1α and eNOS of male obese rats.
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Ghadery et al. (2020) studied Obesity (n=21). High-intensity interval training (HIIT) vs. Control (no training) was evaluated on PGC-1α and eNOS gene expression in heart tissue (p=0.001). Six weeks of high-intensity interval training significantly increased PGC-1α (P=0.001) and eNOS (P=0.001) gene expression in the heart tissue of high-fat diet-induced obese male rats.
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