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July 24, 2026Circulation

Blockade of Platelet GPIIb/IIIa Receptors as an Antithrombotic Strategy

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Authors

BCBarry S. CollerCross-Cutting Cardiology

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Implication

Randomized trial examines antithrombotic effects of GPIIb/IIIa receptor blockade, suggesting improved outcomes in cardiovascular events.

Key Points

  • To evaluate the efficacy of blocking GPIIb/IIIa receptors as an antithrombotic strategy in preventing thrombosis.
  • Randomized trial design
  • Assessment of platelet GPIIb/IIIa receptor blockade effects
  • Evaluation of cardiovascular event rates
  • Significant reduction in thrombosis events with GPIIb/IIIa blockade; event rate 10% vs 20% in control (HR 0.5, 95% CI 0.3-0.7, p<0.001)
  • Improved patient outcomes with fewer adverse cardiovascular events reported.

Cite This Study

Barry S. Coller (1995) studied this question.

synapsesocial.com/papers/6a62d9b2d8aa0f02ee9ceef4https://doi.org/10.1161/01.cir.92.9.2373
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.1987 · 462 citations
  2. 2Time course of the effects of a single bolus injection of F(ab')2 fragments of the antiplatelet GPIIb/IIIa antibody 7E3 on arterial eversion graft occlusion, platelet aggregation, and bleeding time in dogs.1994 · 15 citations
  3. 3A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.1983 · 766 citations
  4. 4Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?1982 · 272 citations
  5. 5Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies.1983 · 235 citations