Key result
Analyses of 69 CVA16 isolates from Taiwan (1998-2021) showed subgenotype B1 was dominant and can cross-neutralize different genotypes, suggesting it as a viable vaccine candidate.
Why the study?
Coxsackievirus A16 frequently caused hand-foot-and-mouth disease outbreaks in Taiwan over the past twenty years, motivating an analysis of its epidemiology and genetic variations from 1998 to 2021.
Population
69 CVA16 isolates collected in Taiwan from 1998 to 2021
Design
Epidemiological and genetic surveillance study
Authors
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Declining CVA16 circulation since 2017 warrants ongoing HFMD surveillance; leaves open drivers of enterovirus dynamics.
Observational (n=69)
The dominant CVA16 genotype B1 demonstrates broad cross-neutralization capabilities, suggesting it is a suitable vaccine candidate.
Cheng et al. (2022) conducted an observational in Coxsackievirus A16 (CVA16) infection (n=69). Coxsackievirus A16 (CVA16) infection was evaluated on Genetic variations and cross-neutralization. Analyses of 69 CVA16 isolates from Taiwan (1998-2021) showed subgenotype B1 was dominant and can cross-neutralize different genotypes, suggesting it as a viable vaccine candidate.
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