Answers are grounded in this paper and cite their sources.
In vitro evaluation shows reduced vancomycin effectiveness against Staphylococcus aureus hemB mutants, suggesting clinical implications.
The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.
No takes yet. Share an insight, caveat, or question.
Tsuji et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: