Case report demonstrates successful adjunctive treatment of endocarditis in a patient with extreme drug resistance, suggesting potential for cefiderocol.
Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.
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Edgeworth et al. (2018) studied this question.
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