Key result
This review summarizes structural and functional data on the SARS-CoV-2 RNA polymerase machinery, highlighting the role of co-factors like Nsp8 and Nsp10 as allosteric activators and connectors.
Why the study?
Viral genome replication is a key stage of the SARS-CoV-2 life cycle, but gaps remain in structural data that is mainly obtained through homology modeling.
Design
Review
Authors
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May support replication-targeted antivirals in COVID-19; leaves open clinical translation pending prospective trials.
This review provides an updated structural and functional understanding of the SARS-CoV-2 RNA replication machinery, which is crucial for developing targeted therapeutic interventions.
Romanò et al. (2020) conducted a review in COVID-19 (SARS-CoV-2). This review summarizes structural and functional data on the SARS-CoV-2 RNA polymerase machinery, highlighting the role of co-factors like Nsp8 and Nsp10 as allosteric activators and connectors.
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