Key result
Electrical nerve stimulation evoked an immediate increase in noradrenaline release from sympathetic terminals in isolated rat tail arteries, which preceded the electrically evoked contraction.
Population
Isolated segment of rat tail artery
Comparison
Electrical nerve stimulation monitored by a… vs Resting conditions (no electrical stimulation)
Design
Preclinical
Authors
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Enables real-time noradrenaline monitoring in isolated arteries; leaves open translation to in vivo cardiovascular physiology.
Differential pulse amperometry with carbon fiber electrodes allows for high-resolution (0.5 s) real-time monitoring of noradrenaline release in isolated arteries, demonstrating that release precedes postsynaptic contraction.
Gonon et al. (1993) studied this question. Electrical nerve stimulation vs. Resting conditions was evaluated on Noradrenaline release (oxidation current at +120 mV). Electrical nerve stimulation evoked an immediate increase in noradrenaline release from sympathetic terminals in isolated rat tail arteries, which preceded the electrically evoked contraction.
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