The isolated perfused rat tail artery is a suitable preparation for assaying sympathomimetic amines but not for angiotensin, vasopressin, or bradykinin due to tachyphylaxis.
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Supports rat tail artery for sympathomimetic assays in vitro; leaves open utility for angiotensin, vasopressin, or bradykinin due to tachyphylaxis.
The isolated perfused tail artery of the rat responds by constriction to 1·0 ng (-)-noradrenaline, and would be suitable for the assay of sympathomimetic amines. Electrical stimulation of this preparation is shown to activate solely postganglionic adrenergic nerve terminals. Tachyphyllaxis to angiotensin, vasopressin and bradykinin preclude the use of this preparation for their assay.
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T. E. Nicholas (1969) studied this question.
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