Key result
Coriolus versicolor attenuates experimental autoimmune myocarditis by suppressing TLR4/NF-κB signaling and inflammation.
Why the study?
The study evaluated the molecular pathways involved in myocarditis using the natural compound Coriolus versicolor in an experimental autoimmune myocarditis model.
Does Coriolus versicolor reduce inflammation, oxidative stress, and tissue injury in an experimental model of autoimmune myocarditis?
Does Coriolus versicolor reduce inflammation, oxidative stress, and tissue injury in an experimental model of autoimmune myocarditis?
Coriolus versicolor demonstrates anti-inflammatory, antioxidant, and antiapoptotic effects in an autoimmune myocarditis animal model by downregulating the TLR4/NF-κB pathway.
Should not change clinical practice in myocarditis; extends preclinical evidence on TLR4/NF-κB modulation but leaves human translation open.
Myocarditis is an inflammatory and oxidative disorder characterized by immune cell recruitment in the damaged tissue and organ dysfunction. In this paper, we evaluated the molecular pathways involved in myocarditis using a natural compound, Coriolus versicolor, in an experimental model of autoimmune myocarditis (EAM). Animals were immunized with an emulsion of pig cardiac myosin and complete Freund’s adjuvant supplemented with mycobacterium tuberculosis; thereafter, Coriolus versicolor (200 mg/Kg) was orally administered for 21 days. At the end of the experiment, blood pressure and heart rate measurements were recorded and the body and heart weights as well. From the molecular point of view, the Coriolus versicolor administration reduced the activation of the TLR4/NF-κB pathway and the levels of pro-inflammatory cytokines (INF-γ, TNF-α, IL-6, IL-17, and IL-2) and restored the levels of anti-inflammatory cytokines (IL-10). These anti-inflammatory effects were accompanied with a reduced lipid peroxidation and nitrite levels and restored the antioxidant enzyme activities (SOD and CAT) and GSH levels. Additionally, it reduced the histological injury and the immune cell recruitment (CD4+ and CD68+ cells). Moreover, we observed an antiapoptotic activity in both intrinsic (Fas/FasL/caspase-3) and extrinsic (Bax/Bcl-2) pathways. Overall, our data showed that Coriolus versicolor administration modulates the TLR4/NF-κB signaling in EAM.
No takes yet. Share an insight, caveat, or question.
Interdonato et al. (2023) studied experimental model of autoimmune myocarditis (EAM). Coriolus versicolor vs. Vehicle was evaluated on Activation of the TLR4/NF-κB pathway and cytokine levels. Coriolus versicolor administration modulated the TLR4/NF-κB pathway, reducing pro-inflammatory cytokines, oxidative stress, immune cell recruitment, and histological injury in an experimental model of autoimmune myocarditis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: