Key result
Emodin (50 mg/kg/day) significantly improved left ventricular function and reduced the severity of experimental autoimmune myocarditis in rats by decreasing TNF-α and IL-1β levels.
Why the study?
Does emodin improve cardiac function and reduce inflammation in a rat model of experimental autoimmune myocarditis?
Population
24 male Lewis rats immunized with porcine cardiac myosin to induce experimental autoimmune myocarditis
Comparison
Emodin 50 mg/kg/day by intragastric… vs Distilled water by intragastric administration…
Design
Preclinical, Randomly assigned into three groups
Follow-up
3 weeks (21 days)
Authors
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Emodin effects remain preclinical in rats; hypothesis-generating for human autoimmune myocarditis trials.
Does emodin improve cardiac function and reduce inflammation in a rat model of experimental autoimmune myocarditis?
Emodin ameliorates experimental autoimmune myocarditis in rats by improving left ventricular function and suppressing proinflammatory cytokines TNF-α and IL-1β via NF-κB inhibition.
Song et al. (2012) studied Experimental Autoimmune Myocarditis (n=24). Emodin vs. Distilled water was evaluated on Left ventricular function and severity of myocarditis. Emodin (50 mg/kg/day) significantly improved left ventricular function and reduced the severity of experimental autoimmune myocarditis in rats by decreasing TNF-α and IL-1β levels.
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