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September 1, 2010Free Radical Research

The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis

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Why the study?

Does edaravone improve cardiac function and attenuate apoptosis in rat models of experimental autoimmune myocarditis?

Population

Rat models of experimental autoimmune myocarditis (EAM) prepared by injection with porcine cardiac myosin.

Comparison

Edaravone administered intraperitoneally at 3 or… vs Vehicle group.

Design

Preclinical

Follow-up

2 weeks

Authors

HSHiroko ShimazakiSumitomo Precision Products (Japan)KWKenichi WatanabeNiigata University of Pharmacy and Medical and Life SciencesPVPunniyakoti T. VeeraveeduChettinad Academy of Research and Education

Discussion

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Implication

Edaravone benefits rat autoimmune myocarditis models; leaves open translation to human disease and should not yet change practice.

Structured PICO

Does edaravone improve cardiac function and attenuate apoptosis in rat models of experimental autoimmune myocarditis?

P
Population
Rat models of experimental autoimmune myocarditis (EAM) prepared by injection with porcine cardiac myosin.
I
Intervention
Edaravone administered intraperitoneally at 3 or 10 mg/kg/day for 2 weeks, starting one week after immunization.
C
Comparator
Vehicle group.
O
Outcome
Cardiac function (measured by haemodynamic and echocardiographic studies) and left ventricular expression of oxidative stress, inflammatory, ER stress, and MAPK proteins, as well as apoptosis (TUNEL assay).surrogate

Edaravone ameliorates the progression of experimental autoimmune myocarditis in rats by inhibiting oxidative and ER stress and subsequent cardiac apoptosis.

Cite This Study

Shimazaki et al. (2010) studied this question.

synapsesocial.com/papers/6a7d7130b97b7d2d4f83ea14https://doi.org/10.3109/10715762.2010.499904

Topics

Myocarditis
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