Key result
Pharmacological interventions such as ACEI and ARBs attenuated myosin-induced inflammation and cardiac fibrosis, improving myocardial function in rats with dilated cardiomyopathy.
Why the study?
Do ACEI and ARBs improve myocardial function and reduce inflammation and fibrosis in rats with DCM after EAM?
Population
Rats with dilated cardiomyopathy (DCM) after experimental autoimmune myocarditis (EAM)
Design
Review
Authors
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Does not support changing DCM management; leaves open translation of anti-inflammatory effects from rat models to humans.
Do ACEI and ARBs improve myocardial function and reduce inflammation and fibrosis in rats with DCM after EAM?
ACE inhibitors and ARBs may attenuate inflammation and cardiac fibrosis, improving myocardial function in experimental autoimmune myocarditis models of dilated cardiomyopathy.
Watanabe et al. (2011) conducted a review in Experimental autoimmune myocarditis and dilated cardiomyopathy. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) was evaluated. Pharmacological interventions such as ACEI and ARBs attenuated myosin-induced inflammation and cardiac fibrosis, improving myocardial function in rats with dilated cardiomyopathy.
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