Key result
Administration of the endothelin receptor antagonist SB209670 exacerbated autoimmune myocarditis in mice, increasing heart-to-body weight ratio and gross inflammatory infiltration.
Why the study?
Does an endothelin receptor antagonist exacerbate autoimmune myocarditis in mice?
Population
BALB/c mice with experimental autoimmune myocarditis induced by immunization of cardiac myosin peptide with…
Comparison
ETA/ETB dual receptor antagonist, SB209670… vs Vehicle-treated mice
Design
Preclinical
Follow-up
2 weeks
Authors
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Suggests caution with endothelin antagonists in myocarditis; leaves open endothelin's protective role in human cardiac inflammation.
Does an endothelin receptor antagonist exacerbate autoimmune myocarditis in mice?
Endothelin receptor antagonism exacerbates autoimmune myocarditis in mice, suggesting endothelin plays a protective role in regulating inflammation in myocarditis.
Tajiri et al. (2014) studied Experimental autoimmune myocarditis. SB209670 (ETA/ETB dual receptor antagonist) vs. vehicle was evaluated on Heart-to-body weight ratio and heart pathology (inflammatory infiltration). Administration of the endothelin receptor antagonist SB209670 exacerbated autoimmune myocarditis in mice, increasing heart-to-body weight ratio and gross inflammatory infiltration.
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