Key result
Vagus nerve stimulation protected against trauma-hemorrhagic shock-induced gut injury, lung injury, and neutrophil priming (P < 0.05) in a spleen-independent manner.
Why the study?
Does vagus nerve stimulation prevent gut injury and systemic organ dysfunction in a rat model of trauma-hemorrhagic shock?
Does vagus nerve stimulation prevent gut injury and systemic organ dysfunction in a rat model of trauma-hemorrhagic shock?
p-value: p=< 0.05
Vagus nerve stimulation prevents systemic organ dysfunction and gut injury following trauma-hemorrhagic shock in a preclinical model, likely via a cholinergic nicotinic receptor pathway.
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Hypothesis-generating for vagus nerve stimulation in trauma-hemorrhagic shock; human trials needed before clinical consideration.
Levy et al. (2012) studied Trauma-hemorrhagic shock. Vagus nerve stimulation (VNS) vs. Sham-VNS or no VNS was evaluated on Gut injury, lung injury, and neutrophil priming (p=< 0.05). Vagus nerve stimulation protected against trauma-hemorrhagic shock-induced gut injury, lung injury, and neutrophil priming (P < 0.05) in a spleen-independent manner.
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