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July 22, 2026The Journal of Organic Chemistry

Rh-Catalyzed Regioselective Hydroxymethylation of Olefins with HCO ₂ Na: A Remarkable Additive Effect

Wenlong Ren Jintao Ou Ying Liu Yian Shi

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Key Points

The aim is to investigate the efficiency of rhodium-catalyzed hydroxymethylation of olefins using sodium formate as an additive.
Conducted rhodium-catalyzed reactions with various olefins and sodium formate as an additive.
Evaluated reaction conditions for optimal efficiency.
Analyzed product distribution to assess regioselectivity.
Significant increases in reaction efficiency observed with sodium formate as an additive.
Demonstrated regioselective hydroxymethylation of multiple olefins.
The use of additives resulted in enhanced yields compared to control experiments.

Implication

Demonstrates enhanced reaction efficiency in olefin hydroxymethylation, indicating a significant additive effect.

Abstract

An effective rhodium-catalyzed regioselective hydroxymethylation of internal and terminal olefins with HCO

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Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6a63008d395161722cd1583c https://doi.org/10.1021/acs.joc.6c00894

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