Rh-Catalyzed Regioselective Hydroxymethylation of Olefins with HCO 2 Na: A Remarkable Additive Effect

Key Points

• The aim is to investigate the efficiency of rhodium-catalyzed hydroxymethylation of olefins using sodium formate as an additive.
• Conducted rhodium-catalyzed reactions with various olefins and sodium formate as an additive.
• Evaluated reaction conditions for optimal efficiency.
• Analyzed product distribution to assess regioselectivity.
• Significant increases in reaction efficiency observed with sodium formate as an additive.
• Demonstrated regioselective hydroxymethylation of multiple olefins.
• The use of additives resulted in enhanced yields compared to control experiments.