Key result
Total cholesterol levels were significantly lower in deceased cancer patients (157 vs 188 mg/dL, p<0.0001) and were a significant predictor of mortality (HR 1.70, p=0.002).
Why the study?
Cardiovascular diseases and cancer share common risk factors, but the relationship between cholesterol levels and mortality in patients undergoing cancer treatment remains to be evaluated.
Are total cholesterol levels associated with mortality in patients receiving anticancer treatment under cardiological surveillance?
Population
551 patients receiving anticancer treatment under regular cardiological surveillance
Comparison
Cholesterol levels across survival status and tumour entities
Design
Cohort study
Follow-up
Median of 41 (95% CI 40, 43) months
Authors
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Lower cholesterol may signal higher mortality risk in cancer; this Level 5 finding leaves open causality and requires prospective validation.
Cohort (n=551)
Are total cholesterol levels associated with mortality in patients receiving anticancer treatment under cardiological surveillance?
Hazard Ratio: 1.7
p-value: p=0.002
Lower total cholesterol levels are associated with increased mortality in cancer patients undergoing cardiological surveillance, highlighting a potential prognostic marker in cardio-oncology.
Hohneck et al. (2021) conducted a cohort in Cancer (n=551). Total cholesterol was evaluated on Mortality (HR 1.70, p=0.002). Total cholesterol levels were significantly lower in deceased cancer patients (157 vs 188 mg/dL, p<0.0001) and were a significant predictor of mortality (HR 1.70, p=0.002).
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