Persistence of Serum Bactericidal Antibody in the First 2-Years After Immunization with Pentavalent Meningococcal ACWYX Vaccine in Malian Infants and Toddlers

Wilbur H. Chen; Fadima Cheick Haidara; Fatoumata DIALLO; Milagritos D. Tapia; Fleesie Hubbard; Mark R. Alderson; William P. Hausdorff; Lionel Martellet; Nancy Hosken; Dhananjay Kapse; Prasad S Kulkarni; Kelly Townsend‐Payne; Ray Borrow; Christine M. Posavad; Clifton W. Kelly; Laina D. Mercer; Samba O Sow; Karen L. Kotloff

doi:10.1093/cid/ciag449

Key Points

The aim is to assess the persistence of serum bactericidal antibodies following immunization with the pentavalent meningococcal vaccine in Malian infants and toddlers.
Analysis of antibody levels in infants and toddlers immunized with the pentavalent meningococcal vaccine.
Data collection performed at baseline and over 2 years post-immunization.
Focus on evaluating the persistence of elevated antibody levels.
Findings show elevated bactericidal antibody levels persist for at least 2 years after vaccination.
Serogroups A, C, W, Y, and X demonstrated sustained immune response post-immunization.

Implication

Examines antibody persistence in infants and toddlers after immunization, indicating long-term efficacy.

Abstract

In 2024, WHO recommended pentavalent meningococcal conjugate vaccine (serogroups A, C, W, Y, and X) for routine infant and toddler immunization in the African meningitis belt. At that time, only short-term data were available regarding persistence of elevated bactericidal antibody levels. This report provides data for the 2 years post-immunization.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a6301a6395161722cd162b2 https://doi.org/10.1093/cid/ciag449

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Persistence of Serum Bactericidal Antibody in the First 2-Years After Immunization with Pentavalent Meningococcal ACWYX Vaccine in Malian Infants and Toddlers

Key Points

Implication

Abstract

Discussion

Cite This Study

Persistence of Serum Bactericidal Antibody in the First 2-Years After Immunization with Pentavalent Meningococcal ACWYX Vaccine in Malian Infants and Toddlers

Key Points

Implication

Abstract

Discussion

Cite This Study

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