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July 24, 2026Cancer Immunology Research

The Gut Microbiome Drives Endogenous T Cell Activation Following CAR-T Cell Therapy

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Authors

KHKejia HuNorth China Electric Power UniversityLJLele JinFirst Affiliated Hospital Zhejiang UniversityZFZidan FengFirst Affiliated Hospital Zhejiang University

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Implication

Randomized trial evaluates gut microbiome's role in T cell activation during CAR-T therapy, suggesting therapeutic targets.

Key Points

  • This research aims to determine how gut microbiota influence endogenous T cell activation following CAR-T therapy.
  • Established a syngeneic CD19+ murine lymphoma model
  • Performed single-cell transcriptomic analyses
  • Conducted 16S RNA sequencing to evaluate gut microbiota changes post-CAR-T infusion.
  • CAR-T infusion activated endogenous CD8+ T cells toward an effector-like phenotype
  • Gut bacteria strains Turicibacter and Parvibacter were identified as critical for CAR-T efficacy
  • Supplementation of these bacteria during CAR-T therapy improved antitumor efficacy and T cell activation.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a6301d3395161722cd16446https://doi.org/10.1158/2326-6066.cir-25-1230
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting the gut microbiota to enhance the antitumor efficacy and attenuate the toxicity of CAR-T cell therapy: a new hope?2024 · 27 citations
  2. 2The Potential of the Gut Microbiota and Butyrate to Enhance CAR-T Cell Therapy in Non-Hodgkin Lymphoma2025
  3. 3Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy2025
  4. 4Longitudinal metagenomic profiling of gut microbiome dynamics in B-cell lymphoma patients receiving CAR-T cell therapy2026
  5. 5IDDF2024-ABS-0409 Recent advances in managing side effects of car-T cell therapy through gut microbiota regulation2024