Key result
Diabetic microangiopathy and macroangiopathy were associated with significantly elevated serum levels of soluble adhesion molecules compared to patients with no complications.
Why the study?
Are serum concentrations of soluble adhesion molecules associated with diabetic microangiopathy and macroangiopathy in patients with Type 2 diabetes?
Population
296 patients with Type 2 diabetes, classified into microangiopathy, macroangiopathy, and no complications.
Design
Cross-sectional
Authors
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Highlights potential biomarker role in diabetic vasculopathy; hypothesis-generating and should not yet change practice.
Observational (n=296)
Are serum concentrations of soluble adhesion molecules associated with diabetic microangiopathy and macroangiopathy in patients with Type 2 diabetes?
Soluble adhesion molecules are elevated in diabetic micro- and macroangiopathy, with potentially greater relative contributions in microangiopathy.
Matsumoto et al. (2002) conducted an observational in Type 2 diabetes (n=296). Diabetic microangiopathy and macroangiopathy vs. No complications (CCA-IMT < 0.9 mm without retinopathy) was evaluated on Serum concentrations of soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin). Diabetic microangiopathy and macroangiopathy were associated with significantly elevated serum levels of soluble adhesion molecules compared to patients with no complications.
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