Key result
Red rice bran extract significantly mitigated high-fat diet-induced hepatosteatosis and improved the serum lipid profile in mice.
Why the study?
Red rice bran extract has known antioxidant and anti-inflammatory properties, but its anti-hepatic steatosis and anti-dyslipidemic effects had not been thoroughly investigated.
Does red rice bran extract alleviate hepatosteatosis and dyslipidemia in high-fat diet-fed mice?
Does red rice bran extract alleviate hepatosteatosis and dyslipidemia in high-fat diet-fed mice?
Red rice bran extract alleviates high-fat diet-induced hepatosteatosis and dyslipidemia in mice by regulating genes involved in lipid metabolism, inflammation, and oxidative stress.
Answers are grounded in this paper and cite their sources.
RRBE may alleviate murine NAFLD; leaves open translation to human steatosis or dyslipidemia.
Red rice bran extract (RRBE) is rich in phytonutrients and has been shown to have anti-diabetic, anti-inflammatory, and antioxidant properties. However, its anti-hepatic steatosis and anti-dyslipidemic properties have not been thoroughly investigated. This study examined the aforementioned properties of RRBE, the underlying mechanism by which it alleviated non-alcoholic fatty liver disease in high-fat diet (HFD)-fed mice, and its major bioactive constituents. The mice were divided into four groups based on their diet: (1) low-fat diet (LFD), (2) LFD with high-dose RRBE (1 g/kg/day), (3) HFD, and (4) HFD with three different doses of RRBE (0.25, 0.5, and 1 g/kg/day). The administration of RRBE, especially at medium and high doses, significantly mitigated HFD-induced hepatosteatosis and concomitantly improved the serum lipid profile. Further, RRBE modified the level of expression of lipid metabolism-related genes (adipose triglyceride lipase (ATGL), cluster of differentiation 36 (CD36), lipoprotein lipase (LPL), liver X receptor alpha (LXRα), sterol regulatory element-binding protein-1c (SREBP-1c), SREBP-2, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and carnitine palmitoyltransferase 1A (CPT1A)) in hepatic or adipose tissues and improved the expression of hepatic high-density lipoprotein cholesterol (HDL-C) cmetabolism-related genes (hepatic lipase (HL) and apolipoprotein A-ǀ (ApoA-ǀ)). RRBE also attenuated markers of liver injury, inflammation, and oxidative stress, accompanied by a modulated expression of inflammatory (nuclear factor-kappa B (NF-κB) and inducible nitric oxide synthase (iNOS)), pro-oxidant (p47phox), and apoptotic (B-cell lymphoma protein 2 (Bcl-2)-associated X and Bcl-2) genes in the liver. High-performance liquid chromatography analyses indicated the presence of protocatechuic acid, γ-oryzanol, vitamin E, and coenzyme Q10 in RRBE. Our data indicate that RRBE alleviates HFD-induced hepatosteatosis, dyslipidemia, and their pathologic complications in part by regulating the expression of key genes involved in lipid metabolism, inflammation, oxidative stress, and apoptosis.
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Munkong et al. (2023) studied Non-alcoholic fatty liver disease and dyslipidemia. Red rice bran extract (RRBE) vs. High-fat diet without RRBE was evaluated on Hepatosteatosis and serum lipid profile. Red rice bran extract significantly mitigated high-fat diet-induced hepatosteatosis and improved the serum lipid profile in mice.
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