Key result
Preoperative temporary discontinuation of aspirin 7 days before surgery did not increase initial blood loss or transfusion rates after total hip arthroplasty compared to no antiplatelet use (P=0.001).
Why the study?
To determine whether preoperative temporary discontinuation of aspirin (100 mg/d) is a safe procedure that does not increase blood loss and transfusion needs after THA.
Does preoperative temporary discontinuation of aspirin for 7 days increase blood loss and transfusion rates in patients undergoing primary total hip arthroplasty compared to those with no history of antiplatelet use?
Cohort (n=219)
Does preoperative temporary discontinuation of aspirin for 7 days increase blood loss and transfusion rates in patients undergoing primary total hip arthroplasty compared to those with no history of antiplatelet use?
Temporary discontinuation of aspirin 7 days prior to primary total hip arthroplasty appears safe and does not increase blood loss or transfusion requirements.
Answers are grounded in this paper and cite their sources.
Discontinuing aspirin 7 days pre-THA was not associated with excess bleeding; leaves open whether this approach is safe pending randomized data.
PURPOSE: This study aims to determine whether preoperative temporary discontinuation of aspirin (100 mg/d) use is a safe procedure does not increase blood loss and the need for transfusion after total hip arthroplasty (THA). MATERIALS AND METHODS: This study retrospectively reviewed 219 patients who underwent consecutive primary THA from January 2012 to December 2018. They were divided into the experimental group (42 cases) that discontinued aspirin intake 7 days before surgery and the control group (150 cases) that had no history of use of antiplatelet agents. To compare initial blood loss between the two groups, we analyzed the changes hemoglobin (Hb) levels and hematocrit values measured preoperatively and in lowest values measured during three days after surgery. In addition, transfusion rate was compared within the first two postoperative weeks between the two groups. A multiple logistic regression was performed to assess the association of transfusion with age, gender, use of antiplatelet agents, preoperative anesthetic risk, body weight and preoperative Hb. CONCLUSION: Preoperative temporary discontinuation of aspirin use for 7 days before surgery did not increase initial blood loss after THA and the need for transfusion in the first two postoperative weeks compared to patients with no history of use of antiplatelet agents.
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Cho et al. (2019) conducted a cohort in Primary total hip arthroplasty (n=219). Preoperative temporary discontinuation of aspirin vs. No history of use of antiplatelet agents was evaluated on Initial blood loss and transfusion rate within the first two postoperative weeks (p==0.001). Preoperative temporary discontinuation of aspirin 7 days before surgery did not increase initial blood loss or transfusion rates after total hip arthroplasty compared to no antiplatelet use (P=0.001).
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