Key result
Aspirin thromboprophylaxis following total hip or knee arthroplasty demonstrated comparable VTE prevention to other anticoagulants (0.15% vs 0%) with a lower incidence of postoperative bleeding (0.6% vs 5.63%).
Why the study?
Venous thromboembolism and pulmonary embolism pose substantial risks after large joint replacement, prompting evaluation of the effectiveness of aspirin for thromboprophylaxis following TKA or THA.
Does aspirin 100 mg daily safely and effectively prevent venous thromboembolism compared to other anticoagulants in patients undergoing total hip or knee arthroplasty?
Population
Patients who underwent total hip or total knee replacement between 2021 and 2023
Comparison
Aspirin vs other anticoagulants
Design
Retrospective database review
Authors
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Aspirin was associated with similar VTE/PE rates versus other anticoagulants post-THA/TKA; leaves open its role as routine prophylaxis pending RCTs.
Cohort (n=1,000)
No
Does aspirin 100 mg daily safely and effectively prevent venous thromboembolism compared to other anticoagulants in patients undergoing total hip or knee arthroplasty?
Absolute Event Rate: 0.15% vs 0%
Aspirin 100 mg daily is a safe and effective alternative to other anticoagulants for VTE prophylaxis following total hip or knee arthroplasty, demonstrating comparable efficacy with a lower incidence of postoperative bleeding.
Benkovich et al. (2025) conducted a cohort in Total hip or knee arthroplasty (n=1,000). Aspirin vs. Other anticoagulants (e.g., rivaroxaban, apixaban, dabigatran, enoxaparin) was evaluated on Postoperative complications (VTE, PE, and bleeding). Aspirin thromboprophylaxis following total hip or knee arthroplasty demonstrated comparable VTE prevention to other anticoagulants (0.15% vs 0%) with a lower incidence of postoperative bleeding (0.6% vs 5.63%).
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