Key result
Sclerostin concentrations were significantly associated with an accelerated increase in pulse wave velocity over 8 years, exclusively in C allele carriers of the rs5186 polymorphism.
Why the study?
The study aimed to establish the association between sclerostin and the development of pulse wave velocity in the general population.
Are sclerostin concentrations associated with the development of arterial stiffening (pulse wave velocity) in the general population?
Cohort (n=522)
Are sclerostin concentrations associated with the development of arterial stiffening (pulse wave velocity) in the general population?
Sclerostin concentrations are associated with accelerated arterial stiffening, specifically in individuals carrying the C allele of the rs5186 polymorphism for the angiotensin II receptor 1.
Should not change clinical practice; leaves open sclerostin’s role in vascular aging and needs prospective validation.
Aim: We aimed to establish the association between sclerostin (a glycoprotein involved in bone metabolism) and development of pulse wave velocity (PWV) in the general population. Methods: A prospective cohort study with a total of 522 subjects. Aortic PWV was measured twice (at baseline and after approximately 8 years of follow-up) and intraindividual change in PWV per year (ΔPWV/year) was calculated. Results: ΔPWV/year increased across the sclerostin quintiles, but generally in a strong age-dependent manner. However, a significant independent positive association between sclerostin and ΔPWV/year was observed exclusively in C allele carriers of rs5186 polymorphism for the angiotensin II receptor 1 (n = 246). Conclusion: Sclerostin concentrations were associated with an accelerated natural course of arterial stiffening, but only in interaction with renin-angiotension system.
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Mayer et al. (2020) conducted a cohort in Arterial stiffening (n=522). Sclerostin was evaluated on Intraindividual change in pulse wave velocity per year (ΔPWV/year). Sclerostin concentrations were significantly associated with an accelerated increase in pulse wave velocity over 8 years, exclusively in C allele carriers of the rs5186 polymorphism.
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