Why the study?
Do genetic variants of the renin-angiotensin-aldosterone system influence the relationship between age and aortic stiffness in untreated hypertensive subjects?
Do genetic variants of the renin-angiotensin-aldosterone system influence the relationship between age and aortic stiffness in untreated hypertensive subjects?
Genetic variants of the angiotensin II type 1 receptor (AT1) influence the progression of arterial stiffness with age in untreated hypertensive patients.
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May flag higher-risk hypertensives for closer monitoring; leaves open whether genotyping should guide therapy.
Lajemi et al. (2001) studied this question.
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