Why the study?
Do renin-angiotensin system polymorphisms affect arterial stiffness in older adults?
Population
3706 older adults from the population-based Rotterdam Study
Comparison
Presence of renin-angiotensin system polymorphisms vs Alternative genotypes/alleles of the same…
Design
Cross-sectional
Authors
Loading...
Does not support RAS genotyping to guide care in older adults; leaves open longitudinal validation of vascular effects.
Do renin-angiotensin system polymorphisms affect arterial stiffness in older adults?
Genetic variation in the renin-angiotensin system, specifically the ACE D-allele, may play a role in determining carotid distensibility and pulse pressure in older adults.
Sie et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: