Why the study?
Is the ACE gene I/D polymorphism associated with arterial distensibility in patients with type 2 diabetes?
Population
137 patients with type 2 diabetes and 260 age-matched healthy control subjects
Comparison
ACE gene insertion/deletion polymorphism vs DD genotype
Design
Case-control
Authors
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II genotype was associated with greater arterial stiffness in type 2 diabetes; leaves open clinical utility of ACE genotyping.
Is the ACE gene I/D polymorphism associated with arterial distensibility in patients with type 2 diabetes?
The ACE gene II genotype is associated with increased aortic and carotid arterial stiffness in patients with type 2 diabetes compared to the DD genotype.
Taniwaki et al. (1999) studied this question.
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