The TC and CC genotypes of the aldosterone synthase gene CYP11B2 in hypertensive subjects were associated with higher heart rate (P<0.05) and lower stroke index (P<0.01) compared to the TT genotype.
Observational (n=425)
Does the aldosterone synthase gene polymorphism CYP11B2 influence age-related changes in blood pressure and arterial stiffness in untreated hypertensive subjects?
The ASGP CYP11B2 TC and CC genotypes are associated with higher heart rate, reduced stroke index, and steeper age-related increases in aortic stiffness in hypertensive men.
p-value: p=<0.05 and <0.01
PURPOSE: In rats, chronic aldosterone administration with high diet intake increases aortic stiffness independent of mechanical stress. In hypertensive humans, enhanced plasma aldosterone and arterial stiffness are positively associated. Whether the aldosterone synthase gene polymorphism (ASGP) CYP11B2 influences the age-related changes in blood pressure (BP) and arterial stiffness in hypertensive subjects has never been investigated. METHODS: In 425 untreated hypertensive men and women, ASGP was evaluated together with aortic pulse wave velocity (PWV). In 191 of these subjects, cardiac haemodynamics were measured using echo-Doppler techniques. RESULTS: In the overall population, independently of sex, the TC and CC genotypes of ASPG had significantly higher heart rate (HR) (P < 0.05) and lower stroke index (P < 0.01) than the TT genotype, but did not affect BP. In men, the adjusted slopes of the curves relating age to PWV and HR were significantly steeper (P = 0.04; P = 0.002) for the TC and CC than for the TT genotype. Such gene-related differences were not observed for the age-systolic BP relationship. CONCLUSION: In hypertensive subjects, the TC and CC genotypes of ASGP involve, by comparison with the TT genotype, significantly higher HR and reduced stroke index. In men with the C allele, the reduced stroke index (cardiac effect) compensates for the steep increase of PWV with age (arterial effect), thus modulating the cardiovascular phenotype and explaining the lack of increased incidence of systolic hypertension. The results are consistent with a local role of endogenous aldosterone on both heart and vessels.
Safar et al. (Fri,) conducted a observational in Hypertension (n=425). Aldosterone synthase gene polymorphism (ASGP) CYP11B2 TC and CC genotypes vs. TT genotype was evaluated on Heart rate and stroke index (p=<0.05 and <0.01). The TC and CC genotypes of the aldosterone synthase gene CYP11B2 in hypertensive subjects were associated with higher heart rate (P<0.05) and lower stroke index (P<0.01) compared to the TT genotype.