December 1, 1996Hypertension
Influence of the Angiotensin II Type 1 Receptor Gene Polymorphism on the Effects of Perindopril and Nitrendipine on Arterial Stiffness in Hypertensive Individuals
Key result
Perindopril reduced pulse wave velocity more in AT1-R C allele carriers than AA homozygotes (-2.85 vs -0.94 m/s; P<0.001), whereas nitrendipine decreased it only in AA homozygotes.
Why the study?
Does the AT1-R A1166C polymorphism influence the effects of perindopril versus nitrendipine on arterial stiffness in hypertensive individuals?
Population
82 hypertensive individuals
Comparison
Perindopril chronic treatment vs Nitrendipine chronic treatment
Design
Cohort
Authors
Discussion
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Implication
AT1-R A1166C genotype may influence differential arterial stiffness responses to perindopril versus nitrendipine; leaves open genotype-guided therapy pending randomized confirmation.
Study Design
Type
Observational (n=82)
Structured PICO
Does the AT1-R A1166C polymorphism influence the effects of perindopril versus nitrendipine on arterial stiffness in hypertensive individuals?
P
Population
82 hypertensive individuals
I
Intervention
Perindopril (angiotensin-converting enzyme inhibitor) chronic treatment
C
Comparator
Nitrendipine (calcium channel blocker) chronic treatment
O
Outcome
Changes in aortic stiffness measured by carotid-femoral pulse wave velocitysurrogate
The AT1-R A1166C genotype predicts opposite responses in arterial stiffness to ACE inhibitors versus calcium channel blockers in hypertensive patients, suggesting a potential role for genotype-guided antihypertensive therapy.
Cite This Study
Bénétos et al. (1996) conducted an observational in Hypertension (n=82). Perindopril vs. Nitrendipine was evaluated on Changes in aortic stiffness (carotid-femoral pulse wave velocity). Perindopril reduced pulse wave velocity more in AT1-R C allele carriers than AA homozygotes (-2.85 vs -0.94 m/s; P<0.001), whereas nitrendipine decreased it only in AA homozygotes.