What does this research mean for the field?

The ACE gene DD genotype is associated with significantly reduced endothelium-dependent vasodilation in never-treated hypertensive patients compared to those with ID or II genotypes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study aims to investigate the association between ACE gene polymorphism and vasodilation in never-treated hypertensives.

April 1, 1998Hypertension

Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Endothelium-Dependent Vasodilation in Never Treated Hypertensive Patients

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Why the study?

Does ACE gene polymorphism affect endothelium-dependent vasodilation in never-treated hypertensive patients?

Population

56 subjects: 32 never-treated hypertensive outpatients and 24 normotensive control subjects.

Comparison

Intra-brachial artery infusion of acetylcholine… vs Normotensive control subjects; and within the…

Design

Cross-sectional

Authors

FPFrancesco PerticoneGeneral Cardiology RCRoberto CeravoloAzienda Ospedaliera Universitaria Pisana RMRaffaele MaioMagna Graecia University

Discussion

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Implication

Supports genetic factors in endothelial dysfunction; hypothesis-generating for ACE polymorphism, should not change practice.

Key Points

This study aims to investigate the association between ACE gene polymorphism and vasodilation in never-treated hypertensives.
32 never-treated hypertensive patients and 24 normotensive controls were analyzed.
Forearm blood flow was measured using strain-gauge plethysmography after drug infusion.
ACE gene polymorphism was determined via polymerase chain reaction.
Hypertensive patients showed significantly reduced forearm blood flow compared to controls (P<.001).
DD genotype hypertensives had lower endothelium-dependent vasodilation than ID+II genotypes (P<.005).
Sodium nitroprusside effects were not statistically different between genotypes.

Structured PICO

Does ACE gene polymorphism affect endothelium-dependent vasodilation in never-treated hypertensive patients?

Population

56 subjects: 32 never-treated hypertensive outpatients (mean age 43+/-7 years, 17 men, 15 women) and 24 normotensive control subjects (mean age 42+/-6 years, 14 men, 10 women).

Intervention

Intra-brachial artery infusion of acetylcholine (7.5, 15, and 30 microg/min) and sodium nitroprusside (0.8, 1.6, and 3.2 microg/min), with stratification by ACE gene deletion (D)/insertion (I) polymorphism.

Comparator

Normotensive control subjects; and within the hypertensive group, DD genotype compared to ID+II genotypes.

Outcome

Forearm blood flow and vascular resistance measured by strain-gauge plethysmography in response to acetylcholine and sodium nitroprusside.surrogate

The ACE DD genotype is associated with more pronounced impairment of endothelium-dependent vasodilation in never-treated hypertensive patients, highlighting a genetic component to endothelial dysfunction in hypertension.

Cite This Study

Perticone et al. (1998) studied this question.

synapsesocial.com/papers/6a1bc122c97d63156a5ee08e https://doi.org/10.1161/01.hyp.31.4.900

Topics

Hypertension management

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Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Endothelium-Dependent Vasodilation in Never Treated Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Endothelium-Dependent Vasodilation in Never Treated Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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