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August 1, 2001Arteriosclerosis Thrombosis and Vascular Biology

ACE Genotype and Endothelium-Dependent Vasodilation of Conduit Arteries and Forearm Microcirculation in Humans

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Why the study?

Does the D allele of the ACE gene affect endothelium-dependent vasodilation in young healthy humans?

Population

92 young healthy individuals

Comparison

Presence of the D allele of the ACE gene vs Other ACE genotypes

Design

Cross-sectional

Authors

GAGuido ArcaroOspedale Sacro Cuore Don CalabriaASAnna SoliniGeneral / Preventive / LipidsTMT MonauniUniversity of Verona

Discussion

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Overview

ACE D allele may mark site-specific femoral endothelial vulnerability in youth; hypothesis-generating for peripheral vascular disease risk.

Structured PICO

Does the D allele of the ACE gene affect endothelium-dependent vasodilation in young healthy humans?

P
Population
92 young healthy individuals
I
Intervention
Presence of the D allele of the ACE gene (deletion [D]/insertion [I] polymorphism)
C
Comparator
Other ACE genotypes
O
Outcome
Endothelium-dependent (flow-mediated) vasodilation in the common femoral artery and brachial artery measured by echo Doppler techniquesurrogate

The D allele of the ACE gene is associated with selective endothelial dysfunction in the femoral artery of young healthy humans, suggesting a potential genetic mechanism for peripheral vascular disease.

Cite This Study

Arcaro et al. (2001) studied this question.

synapsesocial.com/papers/6a7788a52e130d02afeca0f6https://doi.org/10.1161/hq0801.093508

Topics

Women and heart disease
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Also Consider

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