Why the study?
Does the DD ACE genotype associate with blunted endothelial-dependent vasodilatation in normal humans compared to II and ID genotypes?
Population
68 normal human subjects (II: n=25; ID: n=31; DD: n=12), mean ages 24-25 years.
Comparison
DD ACE genotype vs ID and II ACE genotypes
Design
Cross-sectional
Authors
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DD genotype endothelial blunting is hypothesis-generating; leaves open its contribution to hypertension risk.
Does the DD ACE genotype associate with blunted endothelial-dependent vasodilatation in normal humans compared to II and ID genotypes?
The DD ACE genotype is associated with blunted stimulated endothelial NO and donated NO responses in a young, normal population, providing a potential mechanism for increased cardiovascular risk.
Butler et al. (1999) studied this question.
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