Why the study?
Does the ACE DD genotype increase the severity of coronary atherosclerosis in patients with acute coronary syndromes, and is this effect modified by smoking?
Population
152 Japanese patients with acute coronary syndromes and 399 healthy individuals
Comparison
Angiotensin-converting enzyme (ACE) DD genotype vs Angiotensin-converting enzyme ID or II genotype
Design
Case-control
Authors
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DD genotype associated with greater CAD extent in smoking ACS patients; hypothesis-generating for gene-environment interaction, needs prospective validation.
Does the ACE DD genotype increase the severity of coronary atherosclerosis in patients with acute coronary syndromes, and is this effect modified by smoking?
The ACE DD genotype is associated with more severe angiographic coronary atherosclerosis specifically in smokers presenting with acute coronary syndromes, highlighting a gene-environment interaction.
Hibi et al. (1997) studied this question.
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