Key result
Timolol given five minutes after coronary occlusion in cats did not modify the occurrence of arrhythmias or the associated increase in plasma norepinephrine and epinephrine.
Why the study?
Does timolol prevent coronary occlusion-induced arrhythmias and the associated increase in plasma catecholamines in an anesthetized cat model?
Does timolol prevent coronary occlusion-induced arrhythmias and the associated increase in plasma catecholamines in an anesthetized cat model?
In a feline model of acute coronary occlusion, intravenous timolol administered five minutes post-occlusion failed to prevent arrhythmias or the associated rise in plasma catecholamines.
Timolol post-occlusion fails to reduce arrhythmias in this feline model; leaves open any protective role for beta-blockade in human acute ischemia.
The reported study determined whether timolol would afford a protective effect by preventing the coronary occlusion-induced arrhythmias associated with the increase in plasma norepinephrine (NE) and epinephrine (E). Ten anesthetized cats received saline or timolol (5 mg/kg, IV) five minutes after coronary occlusion of the left anterior descending coronary artery 10 to 14 mm below its origin. Coronary occlusion produced arrhythmia in three of the cats that received saline and in four of the cats that received timolol. Three of the saline-treated cats died in cardiogenic shock; two were sacrificed six hours postocclusion. Four of the timolol-treated cats died in congestive heart failure postcoronary occlusion. There was a gradual increase in NE (P greater than .05) and E (P less than .05) in both groups after coronary occlusion. Death produced a significant increase in NE and E levels. Timolol did not modify the occurrence of arrhythmias and the associated increase in plasma NE and E that developed after coronary occlusion and at death.
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Lathers et al. (1988) studied Coronary occlusion-induced arrhythmias (n=10). Timolol vs. Saline was evaluated on Occurrence of arrhythmias and increase in plasma norepinephrine and epinephrine. Timolol given five minutes after coronary occlusion in cats did not modify the occurrence of arrhythmias or the associated increase in plasma norepinephrine and epinephrine.
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