Why the study?
Does chronic timolol alter beta-receptor density and sympathetic neural discharge in an animal model of myocardial infarction?
Population
Cats
Comparison
Timolol (5 mg/kg, PO, for 1, 2, or 8 weeks) vs No drug (control cats)
Design
Preclinical
Follow-up
Up to 8 weeks
Authors
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Chronic timolol upregulates myocardial beta-receptors in feline MI without extending occlusion survival; hypothesis-generating for sympathetic modulation, requires higher-species validation.
Does chronic timolol alter beta-receptor density and sympathetic neural discharge in an animal model of myocardial infarction?
Chronic timolol administration in a feline model of myocardial infarction increases myocardial beta-receptor density, which may alter synaptic norepinephrine dynamics during acute coronary occlusion.
Lathers et al. (1988) studied this question.
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