Key result
IV timolol before coronary ligation reduces lipid accumulation in borderline ischemic myocardium by ~24%.
Why the study?
The effects of non-selective beta adrenergic blockade on intracellular lipid accumulation in acutely ischaemic myocardium were not well characterized.
Does timolol reduce intracellular lipid accumulation in acute ischaemia in cats with coronary ligation?
Comparison
Timolol intravenously before ligation vs control
Design
Electron microscopy with quantitative stereological techniques in an experimental study
Follow-up
3 hours
Authors
Loading...
Does not support clinical use; leaves open whether reduced lipid accumulation translates to human benefit.
Does timolol reduce intracellular lipid accumulation in acute ischaemia in cats with coronary ligation?
Effect estimate: 24% reduction
Absolute Event Rate: 4.97% vs 6.53%
In a feline model of acute ischemia, timolol diminished lipid accumulation in borderline myocardial tissue, likely due to reduced ischemic intensity and better preserved metabolic function.
Grong et al. (1986) studied Acute myocardial ischaemia (n=16). Timolol vs. Control was evaluated on Cytosolic volume fraction of lipids in borderline myocardial tissue (24% reduction). Intravenous timolol administered before coronary ligation reduced lipid accumulation in borderline ischaemic myocardial tissue by 24% compared with controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: