Key result
Timolol protects myocardium during ischemia in cats by lessening ATP depletion via reduced cardiac performance.
Why the study?
The effects of the beta-adrenergic blocker timolol on cardiac function and adenine nucleotide metabolism during acute regional ischaemia were unclear.
Population
Cats with 45 min acute regional ischaemia following coronary occlusion
Comparison
Timolol-treated cats vs untreated control cats
Design
Experimental study measuring myocardial blood flow and nucleotide metabolism
Authors
Loading...
Caution against clinical use of timolol for ischemic protection; leaves open human translation of feline findings.
STANGELAND et al. (1984) studied acute regional ischaemia. timolol vs. untreated cats was evaluated on cardiac function and adenine nucleotide metabolism. Timolol protected the myocardium during a 45-minute ischaemic period in cats by lessening ATP depletion and energy charge reduction, likely due to reduced overall cardiac performance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: