Key result
Timolol (2.5 mg i.v.) reduced myocardial oxygen consumption and cardiac venous flow at rest, but did not reduce MVO2 and metabolic ischaemia during pacing-induced angina.
Why the study?
Does timolol improve coronary haemodynamics and myocardial metabolism during pacing-induced angina in patients with angina pectoris?
Population
26 patients with angina pectoris
Comparison
Timolol 2.5 mg i.v. vs Baseline measurements prior to timolol…
Design
Other
Authors
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Timolol's resting effects may not extend to demand ischemia; hypothesis-generating for beta-blocker metabolism in angina.
Does timolol improve coronary haemodynamics and myocardial metabolism during pacing-induced angina in patients with angina pectoris?
Intravenous timolol reduces myocardial oxygen consumption at rest but fails to alleviate metabolic ischemia or reduce oxygen consumption during pacing-induced angina.
Simonsen et al. (1983) studied Angina pectoris (n=26). Timolol vs. Baseline/pre-treatment was evaluated on Coronary haemodynamics and myocardial metabolism (MVO2, CVF, MLE). Timolol (2.5 mg i.v.) reduced myocardial oxygen consumption and cardiac venous flow at rest, but did not reduce MVO2 and metabolic ischaemia during pacing-induced angina.
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