Key result
Intravenous beta-blockers with intrinsic sympathomimetic activity induced significantly less depression of left ventricular function than those without this property in coronary heart disease.
Why the study?
Do intravenous beta-blockers with intrinsic sympathomimetic activity cause less depression of left ventricular function compared to those without in patients with coronary heart disease?
Population
24 patients with coronary heart disease
Comparison
Intravenous beta-blockers with intrinsic… vs Intravenous beta-blockers without intrinsic…
Design
Other
Authors
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Questions clinical relevance of ancillary beta-blocker properties for LV effects in CHD; leaves open larger comparative trials.
Do intravenous beta-blockers with intrinsic sympathomimetic activity cause less depression of left ventricular function compared to those without in patients with coronary heart disease?
Intravenous beta-blockers with intrinsic sympathomimetic activity appear to be more effective in maintaining cardiac function than those without this property in patients with coronary heart disease.
Taylor et al. (1982) studied coronary heart disease (n=24). Intravenous beta-blockers with intrinsic sympathomimetic activity (practolol and oxprenolol) vs. Intravenous beta-blockers without intrinsic sympathomimetic activity (propranolol or metoprolol) was evaluated on depression of left ventricular function (relation between left ventricular filling pressure and cardiac output at rest and during exercise). Intravenous beta-blockers with intrinsic sympathomimetic activity induced significantly less depression of left ventricular function than those without this property in coronary heart disease.
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