Key result
Among 26 patients with malignant fibrous histiocytoma of the spermatic cord, 5 were long-term survivors (>5 years), 5 had disease recurrence, and 3 died from metastatic tumor.
Malignant fibrous histiocytoma of the spermatic cord has a relatively favorable prognosis when treated with radical orchiectomy, though late recurrences and metastases necessitate long-term followup.
PURPOSE: We analyzed 26 cases of malignant fibrous histiocytoma and report our conclusions regarding the diagnosis, pathology and treatment of this unusual tumor. MATERIALS AND METHODS: We reviewed 25 previously reported cases of malignant fibrous histiocytoma of the spermatic cord and report 1 additional case. Further data on patient survival and tumor recurrence rates were obtained from some of the previous authors. RESULTS: Of 26 patients 5 are long-term survivors (more than 5 years). Longest reported followup is 14 years. However, malignant fibrous histiocytoma has recurred as late as 6 years after surgery. To date 4 deaths have been reported, including 1 unrelated to the tumor and 3 from metastatic tumor. Disease recurred in 5 patients. In no case was there local lymph node involvement at surgery. CONCLUSIONS: Malignant fibrous histiocytoma presents earlier in the spermatic cord than at other sites and seems to have a more favorable prognosis. Ultrasound may aid in the diagnosis. Definitive treatment is radical orchiectomy but localized radiotherapy may decrease local recurrence rates. Satellite lesions at surgery indicate a poorer prognosis. Metastases may develop late in the lungs or mesentery, and so long-term followup is necessary.
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Glazier et al. (1996) conducted a review in Malignant fibrous histiocytoma of the spermatic cord (n=26). Malignant fibrous histiocytoma of the spermatic cord was evaluated on Patient survival and tumor recurrence. Among 26 patients with malignant fibrous histiocytoma of the spermatic cord, 5 were long-term survivors (>5 years), 5 had disease recurrence, and 3 died from metastatic tumor.
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