Key result
In a retrospective evaluation of 24 patients with malignant fibrous histiocytoma, local recurrence and distant metastases were frequent, with wide local excision being the most important treatment.
Observational (n=24)
Malignant fibrous histiocytoma is a soft tissue sarcoma with frequent local recurrence and high incidence of distant metastases, for which wide local excision is the primary treatment.
Supports wide local excision emphasis in MFH; leaves open optimal multimodal strategies given high recurrence rates in small retrospective data.
Twenty-four patients with malignant fibrous histiocytoma are being analyzed: 54.2% occurred in the sixth, seventh, and eighth decades of life; 45.8% were located in the extremities. This is a soft tissue sarcoma noted for its pleomorphic histologic appearance. It is postulated that the origin cell is a histiocyte. The local recurrence of metastatic potential of this tumor is difficult to predict from its histological features. Local recurrence after complete excision is frequent. Also, there is a high incidence of distant metastases. Wide local excision with a wide margin around the tumor is the most important treatment modality. The use of postoperative radiotherapy and chemotherapy needs to be evaluated.
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Tewfik et al. (1981) conducted an observational in Malignant fibrous histiocytoma (n=24). Wide local excision was evaluated. In a retrospective evaluation of 24 patients with malignant fibrous histiocytoma, local recurrence and distant metastases were frequent, with wide local excision being the most important treatment.
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