Key result
Novel pharmacotherapy and interventional techniques such as renal denervation and baroreflex activation therapy are being developed to address uncontrolled essential hypertension.
Why the study?
Despite numerous available antihypertensive drug classes, patients still develop uncontrolled hypertension, driving a continuous need for novel agents and interventional techniques.
This review highlights emerging pharmacological and interventional strategies, such as renal denervation and baroreflex activation therapy, for managing uncontrolled essential hypertension.
Essential hypertension is an important cause of cardiovascular morbidity and mortality worldwide with significant clinical and economic implications. The field of antihypertensive treatment already numbers numerous agents and classes of drugs. However, patients are still developing uncontrolled hypertension. Hence there is a continuous need for novel agents with good tolerability. Advances in this field are focusing both on pharmacotherapy, with the developments in traditional and non-traditional targets, as well as interventional techniques such as renal denervation and baroreflex activation therapy. It is likely that future strategies may involve a tailored approach to the individual patient, with genetic modulation playing a key role.
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Christophides et al. (2020) conducted a review in Essential hypertension. Novel pharmacotherapy and interventional techniques was evaluated. Novel pharmacotherapy and interventional techniques such as renal denervation and baroreflex activation therapy are being developed to address uncontrolled essential hypertension.
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