Key result
Endotoxin administration in cirrhotic rats led to a significant increase in sample asymmetry (P=0.0008) and prolongation of memory length for decelerating perturbations in the cardiac rhythm.
Why the study?
Does endotoxin administration alter sample asymmetry and memory length of cardiac time-series in cirrhotic rats?
Does endotoxin administration alter sample asymmetry and memory length of cardiac time-series in cirrhotic rats?
Answers are grounded in this paper and cite their sources.
Endotoxin administration in cirrhotic rats induces transient heart rate decelerations and increased sample asymmetry, suggesting these HRV parameters have potential as physiomarkers for early sepsis detection in cirrhosis.
). Changes in sample asymmetry and memory length of cardiac time-series were studied in conscious rats using implanted telemetric probes. Cirrhotic (but not control) rats exhibited increased sample asymmetry following endotoxin injection, which was consistent with the development of transient heart rate deceleration. Endotoxin administration in cirrhotic rats was associated with prolongation of memory length for observing decelerating perturbations in the cardiac rhythm. These findings may have application in the development of an HRV monitoring system for early detection of sepsis in cirrhosis.
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Taghipour et al. (2016) studied Cirrhosis and Endotoxemia. Endotoxin (LPS) vs. Saline was evaluated on Sample asymmetry of cardiac time-series (p=0.0008). Endotoxin administration in cirrhotic rats led to a significant increase in sample asymmetry (P=0.0008) and prolongation of memory length for decelerating perturbations in the cardiac rhythm.
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