Why the study?
Does colloid (pentastarch) fluid resuscitation improve endotoxin-induced myocardial dysfunction compared to crystalloid (saline) in rats?
Population
Pathogen-free male Wistar rats given intraperitoneal injection of endotoxin or phosphate-buffered solution…
Comparison
Colloid (pentastarch) fluid resuscitation vs Crystalloid fluid resuscitation or unchallenged…
Design
Preclinical
Follow-up
up to 48 hrs
Authors
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Rat data do not justify pentastarch in human sepsis; leaves open colloid benefit in endotoxin cardiomyopathy.
Does colloid (pentastarch) fluid resuscitation improve endotoxin-induced myocardial dysfunction compared to crystalloid (saline) in rats?
In a rat model of endotoxin-induced myocardial dysfunction, fluid resuscitation with pentastarch was more beneficial than saline in reversing echocardiographic and biomarker abnormalities.
Chagnon et al. (2005) studied this question.
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