The view that an intact thymus-dependent immune system is both necessary and sufficient for acute allograft rejection is not controversial and T lymphocytes fulfill a form of Koch's postulates in this regard (1): (A) they invariably are present in rejecting allografts; (B) rejection is abrogated by depriving hosts of T cells; (C) alloreactive T cells can be isolated and propagated in vitro; and (D) rejection capacity is readily transferred to incapacitated hosts with purified T cells; the controversy is over which T cell subset actually mediates rejection.
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David Steinmuller (1985) studied this question.