Key result
Radionuclide angiography during right atrial pacing revealed abnormal left ventricular function curves in 90% (18 of 20) of patients with coronary artery disease compared to normal subjects.
Why the study?
Does radionuclide angiography during right atrial pacing differentiate left ventricular function curves between normal subjects and patients with coronary artery disease?
Observational (n=27)
Does radionuclide angiography during right atrial pacing differentiate left ventricular function curves between normal subjects and patients with coronary artery disease?
Radionuclide angiography during atrial pacing can construct left ventricular function curves that effectively distinguish normal systolic function from ischemic dysfunction in patients with coronary artery disease.
We used radionuclide angiography during right atrial pacing to assess left ventricular function in 7 normal subjects and 20 patients with coronary artery disease. A left ventricular function curve relating stroke volume to end-diastolic volume was plotted for each patient. The normal pacing ventricular function curve was a straight line passing through the origin of axes. The pacing ventricular function curve was abnormal in 18 of the 20 patients with coronary artery disease, and three different shaped curves were obtained, reflecting decreased contractile force for the same end-diastolic volume during ischemia. Cardiac output and blood pressure do not change during atrial pacing, thus the Frank-Starling relationship is evaluated by this method during almost experimentally controlled conditions. Relating stroke volume to end-diastolic volume, and not end-diastolic pressure, distinguishes between overall left ventricular systolic function and left ventricular compliance.
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Rozenman et al. (1986) conducted an observational in Coronary artery disease (n=27). Radionuclide angiography during right atrial pacing vs. Normal subjects was evaluated on Abnormal pacing ventricular function curve. Radionuclide angiography during right atrial pacing revealed abnormal left ventricular function curves in 90% (18 of 20) of patients with coronary artery disease compared to normal subjects.
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