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With the technique of right atrial pacing, left ventricular function was assessed in 21 normal subjects and in 13 patients with elevated left ventricular filling pressures. Since cardiac output does not change significantly with atrial pacing, the stroke volume decreases as an inverse function of the pacing rate. Stroke volume can thus be varied over a wide range, and by simultaneous measurement of left ventricular end-diastolic pressure, pacing ventricular function curves can be obtained. The calculated average slope for the ventricular function curve relating stroke volume index to left ventricular end-diastolic pressure was steeper in the normal subjects than in the group with elevated left ventricular end-diastolic pressure, but considerable overlap occurred between the groups. However, in individual patients the pacing ventricular function curve appears useful in assessment of the effect of interventions that augment or depress ventricular performance.
Parker et al. (Mon,) studied this question.