Key result
Propranolol and atenolol produced similar immediate effects on coronary dynamics, with neither showing significant coronary vasoconstrictor properties during rapid atrial pacing.
Why the study?
Does selective versus non-selective beta-adrenergic blockade differentially affect coronary dynamics in patients with suspected coronary artery disease?
Population
12 patients undergoing cardiac catheterisation for suspected coronary artery disease
Comparison
Propranolol and atenolol administration assessed… vs Comparison between propranolol and atenolol, as…
Design
Other
Follow-up
Immediate (during cardiac catheterisation)
Authors
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Cardioselectivity may not influence acute coronary dynamics; leaves open relevance in chronic CAD or other settings.
Does selective versus non-selective beta-adrenergic blockade differentially affect coronary dynamics in patients with suspected coronary artery disease?
Cardioselectivity appears to be unimportant with respect to beta-adrenergic blockade and coronary circulation, as neither propranolol nor atenolol demonstrated significant coronary vasoconstrictor properties.
Stephens et al. (1978) studied Suspected coronary artery disease (n=12). Propranolol and atenolol was evaluated on Coronary dynamics (myocardial blood flow, heart rate, myocardial oxygen consumption). Propranolol and atenolol produced similar immediate effects on coronary dynamics, with neither showing significant coronary vasoconstrictor properties during rapid atrial pacing.